[Relation of genetic polymorphism of XRCC1 with risks of chronic benzene poisoning].

OBJECTIVE

To explore the relation between genetic polymorphisms in XRCC1 and risks of chronic benzene poisoning (BP).

METHODS

A case-control study was conducted. 152 BP patients and 152 workers occupationally exposed to benzene without poisoning manifestations were investigated. PCR-RFLP was applied to detect the single nucleotide polymorphisms (SNPs) on c.194, c.280 and c.399 of XRCC1 gene.

RESULTS

The proportion of XRCC1 c.194Arg/Trp + Trp/Trp genotypes in the case group was lower than that of the control group, while there was a higher proportion for XRCC1 C.280Arg/His + His/His in the case group. There was a 1.67-fold decreased risk of BP for individuals carrying XRCC1 C.194Arg/Trp + Trp/Trp genotypes (OR adj = 0.60, 95% CI: 0.37-0.97, P = 0.039) compared with subjects carrying Arg/Arg allele, and individuals carrying genotypes of XRCC1 C.280Arg/His + His/His had a 1.91-fold increased risk of BP compared with these carrying the wild allele (OR adj = 1.91, 95% CI: 1.17-3.10, P = 0.009).

CONCLUSION

The risk of BP for subjects carrying XRCC1 c.194Arg/Trp + Trp/Trp genotypes may decrease while for individuals carrying XRCC1 c.280Arg/His + His/His genotypes may increase.