Bevan John S
Department of Endocrinology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, Scotland, United Kingdom.
J Clin Endocrinol Metab. 2005 Mar;90(3):1856-63. doi: 10.1210/jc.2004-1093. Epub 2004 Dec 21.
Somatostatin analogs are the mainstay of medical therapy for acromegaly. Suppression of GH hypersecretion, lowering of IGF-I production, and control of symptoms are established benefits of therapy. In addition, clinically significant tumor shrinkage has been seen in a number of studies, particularly in patients undergoing primary medical therapy. This review summarizes current knowledge of the effects of somatostatin analogs on tumor size and cellular morphology and examines the available data on predictors of tumor shrinkage.
生长抑素类似物是肢端肥大症药物治疗的主要手段。抑制生长激素分泌过多、降低胰岛素样生长因子-1的产生以及控制症状是该疗法已确定的益处。此外，在多项研究中已观察到具有临床意义的肿瘤缩小，尤其是在接受初始药物治疗的患者中。本综述总结了目前关于生长抑素类似物对肿瘤大小和细胞形态影响的知识，并审视了有关肿瘤缩小预测因素的现有数据。
