Mai R, Reinsdorf A, Pilling E, Lauer G, Gelinsky M, Eckelt U
Klinik für Mund-, Kiefer- und Gesichtschirurgie, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden.
Mund Kiefer Gesichtschir. 2005 Jan;9(1):12-7. doi: 10.1007/s10006-004-0587-z.
In the following study we evaluated the biological response of a new freely moldable bone substitute in an animal model.
Critically sized defects were created surgically in the lower jaw of ten adult minipigs. The drill defects were filled with hydroxyapatite collagen paste. After observation periods of 1, 3, 6, 12, and 18 months the mandibles were harvested without wound healing defects for histological evaluation of resorption and bone ingrowth with a sawing and grinding technique.
The result of the remodeling process was a complete degradation of hydroxyapatite collagen implants after 12-18 months with reorganization of vital trabeculae oriented in a mature pattern.
The hydroxyapatite collagen cement works as an osteoconductor and shows signs of direct osseointegration and resorption.
在以下研究中，我们在动物模型中评估了一种新型可自由塑形骨替代物的生物学反应。
在10只成年小型猪的下颌骨上通过手术制造临界尺寸的缺损。钻孔缺损用羟基磷灰石胶原糊剂填充。在1、3、6、12和18个月的观察期后，采集下颌骨，无伤口愈合缺损，采用锯切和研磨技术进行吸收和骨长入的组织学评估。
重塑过程的结果是，12 - 18个月后羟基磷灰石胶原植入物完全降解，重要小梁以成熟模式重新排列。
羟基磷灰石胶原骨水泥起骨传导作用，并显示出直接骨整合和吸收的迹象。
