Siems W, Brenke R
Institute of Biochemistry, Medical Faculty (Charité), Humboldt University, Berlin, Federal Republic of Germany.
Arctic Med Res. 1992 Jan;51(1):3-9.
The red cell glutathione levels of 10 healthy volunteers who are accustomed to winter-swimming were measured before and after this short-term whole body exposition to hypothermic environment. From the increases of the erythrocytic level of oxidized glutathione (GSSG) and of GSSG: total glutathione ratio an extensive formation of oxygen free radicals during and following the exposition to the intensive cold stimulus was concluded. That is in accordance with the finding on the drastic decrease of the concentration of uric acid as an important radical scavenger of the human blood plasma. Furthermore, the initial erythrocytic concentrations of reduced glutathione (GSH) and GSSG of subjects accustomed to winter-swimming were compared with those of healthy control persons who are not accustomed to regular winter-swimming. The markedly increased concentration of GSH and the reduced GSSG:total glutathione ratio in the erythrocytes of winter-swimmers reflect the adaptation to a regular oxidative stress. This antioxidative adaptation is postulated as a new basic mechanism of the hardening by exposition to an intensive short-term cold stimulus often applied within the hydrotherapy.
对10名习惯冬泳的健康志愿者在短期全身暴露于低温环境前后的红细胞谷胱甘肽水平进行了测量。从氧化型谷胱甘肽（GSSG）的红细胞水平以及GSSG：总谷胱甘肽比率的增加可以得出结论，在暴露于强烈寒冷刺激期间及之后会大量形成氧自由基。这与人体血浆中重要的自由基清除剂尿酸浓度急剧下降的发现一致。此外，将习惯冬泳的受试者的红细胞中还原型谷胱甘肽（GSH）和GSSG的初始浓度与不习惯定期冬泳的健康对照者的浓度进行了比较。冬泳者红细胞中GSH浓度显著增加以及GSSG：总谷胱甘肽比率降低，反映了对常规氧化应激的适应。这种抗氧化适应被假定为水疗中经常应用的短期强烈寒冷刺激强化作用的一种新的基本机制。
