Siems W G, Brenke R, Sommerburg O, Grune T
Herzog-Julius Hospital for Rheumatology and Orthopaedics, Bad Harzburg, Germany.
QJM. 1999 Apr;92(4):193-8. doi: 10.1093/qjmed/92.4.193.
Adaptation to oxidative stress is an improved ability to resist the damaging effects of reactive oxygen species, resulting from pre-exposure to a lower dose. Changes in uric acid and glutathione levels during ice-bathing suggest that the intensive voluntary short-term cold exposure of winter swimming produces oxidative stress. We investigated whether the repeated oxidative stress in winter swimmers results in improved antioxidative adaptation. We obtained venous blood samples from winter swimmers and determined important components of the antioxidative defense system in the erythrocytes or blood plasma: reduced and oxidized glutathione (GSH and GSSG), and the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (Cat). The control group consisted of healthy people who had never participated in winter swimming. The baseline concentration of GSH and the activities of erythrocytic SOD and Cat, were higher in winter swimmers. We interpret this as an adaptative response to repeated oxidative stress, and postulate it as a new basic molecular mechanism of increased tolerance to environmental stress.
对氧化应激的适应是指由于预先暴露于较低剂量的活性氧而提高了抵抗其破坏作用的能力。冰浴期间尿酸和谷胱甘肽水平的变化表明，冬季游泳时强烈的自愿短期冷暴露会产生氧化应激。我们研究了冬季游泳者反复出现的氧化应激是否会导致抗氧化适应能力的提高。我们从冬季游泳者身上采集静脉血样本，并测定红细胞或血浆中抗氧化防御系统的重要成分：还原型和氧化型谷胱甘肽（GSH和GSSG），以及超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）和过氧化氢酶（Cat）的活性。对照组由从未参加过冬季游泳的健康人组成。冬季游泳者的GSH基线浓度以及红细胞SOD和Cat的活性较高。我们将此解释为对反复氧化应激的适应性反应，并将其假定为提高对环境应激耐受性的一种新的基本分子机制。
