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TiCl4-promoted multicomponent reaction: a new entry to functionalized alpha-amino acids.

作者信息

Ghosh Arun K, Xu Chun-Xiao, Kulkarni Sarang S, Wink Donald

机构信息

Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, USA.

出版信息

Org Lett. 2005 Jan 6;7(1):7-10. doi: 10.1021/ol048302j.

DOI:10.1021/ol048302j
PMID:15624964
Abstract

TiCl(4)-promoted multicomponent reactions involving N-tosyl imino ester, cyclic enol ether, and silane reagents in a single one-pot operation provide functionalized alpha-amino acids with multiple stereogenic centers in good to excellent yields. Cis/trans selectivities with optically active substituted dihydrofurans have been investigated.

摘要

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