捕捉有机合成的精髓：从生物活性天然产物到当今药物设计的分子。
Capturing the essence of organic synthesis: from bioactive natural products to designed molecules in today's medicine.
机构信息
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA.
出版信息
J Org Chem. 2010 Dec 3;75(23):7967-89. doi: 10.1021/jo101606g. Epub 2010 Oct 11.
Abstract
In this Perspective, I outline my group's research involving the chemical syntheses of medicinally important natural products, exploration of their bioactivity, and the development of new asymmetric carbon-carbon bond-forming reactions. This paper also highlights our approach to molecular design and synthesis of conceptually novel inhibitors against target proteins involved in the pathogenesis of human diseases, including AIDS and Alzheimer's disease.
摘要
在这篇观点文章中，我概述了我的团队在涉及具有医学重要性的天然产物的化学合成、生物活性探索以及新的不对称碳-碳键形成反应的开发方面的研究。本文还强调了我们针对涉及人类疾病发病机制的靶蛋白（包括艾滋病和老年痴呆症）的概念新颖的抑制剂的分子设计和合成方法。
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