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Capturing the essence of organic synthesis: from bioactive natural products to designed molecules in today's medicine.捕捉有机合成的精髓：从生物活性天然产物到当今药物设计的分子。
J Org Chem. 2010 Dec 3;75(23):7967-89. doi: 10.1021/jo101606g. Epub 2010 Oct 11.
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Total synthesis of the marine natural product (-)-clavosolide A.海洋天然产物（-）-克拉沃索利德A的全合成。
Org Lett. 2006 Jul 20;8(15):3319-22. doi: 10.1021/ol0611705.
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Polyketide construction via hydrohydroxyalkylation and related alcohol C-H functionalizations: reinventing the chemistry of carbonyl addition.通过氢羟烷基化和相关醇 C-H 官能团化构建聚酮：重新创造羰基加成的化学。
Nat Prod Rep. 2014 Apr;31(4):504-13. doi: 10.1039/c3np70076c. Epub 2014 Feb 11.
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Formal synthesis of palmerolide A, featuring alkynogenic fragmentation and syn-selective vinylogous aldol chemistry. Palmerolide A 的全合成，其特征为炔丙基断裂反应和 syn-选择性的 vinylogous 羟醛缩合反应。
Org Lett. 2013 Feb 15;15(4):886-9. doi: 10.1021/ol400014e. Epub 2013 Feb 1.
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Controlling the facial selectivity of asymmetric [4+2] cyclo-additions: a concise synthesis of the cis-decalin core structure of superstolides A and B.控制不对称 [4+2]环加成的面选择性：超托里内酯 A 和 B 的顺式十氢萘核结构的简洁合成。
Org Lett. 2011 Jul 15;13(14):3580-3. doi: 10.1021/ol201095b. Epub 2011 Jun 14.
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De Novo Asymmetric Synthesis of Phoracantholide J.从头不对称合成千里光菲灵。
Org Lett. 2016 Oct 7;18(19):4970-4973. doi: 10.1021/acs.orglett.6b02432. Epub 2016 Sep 16.
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Total synthesis of the marine natural product (-)-clavosolide A. A showcase for the Petasis-Ferrier union/rearrangement tactic.海洋天然产物（-）-克拉沃索利德A的全合成。Petasis-Ferrier联合/重排策略的一个范例。
Org Lett. 2006 Jul 20;8(15):3315-8. doi: 10.1021/ol0611752.
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Total synthesis of (+)-lasonolide A.（+）-拉索内酯A的全合成。
Org Lett. 2006 Feb 2;8(3):475-8. doi: 10.1021/ol0527678.
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Studies toward the Synthesis of Amphidinolide C1: Stereoselective Construction of the C(1)-C(15) Segment.朝向 Amphidinolide C1 的合成研究：C(1)-C(15) 片段的立体选择性构建。
Org Lett. 2020 Dec 4;22(23):9174-9177. doi: 10.1021/acs.orglett.0c03134. Epub 2020 Nov 12.
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Synthesis of iriomoteolide-1a C13-C23 fragment via asymmetric conjugate addition and Julia-Kocienski coupling reaction.通过不对称共轭加成和Julia-Kocienski偶联反应合成西表岛内酯-1a的C13-C23片段。
Org Lett. 2009 Aug 20;11(16):3674-6. doi: 10.1021/ol901480s.
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Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance.超越达芦那韦：新一代 HIV-1 蛋白酶抑制剂抵抗耐药性的最新进展。
Chem Commun (Camb). 2022 Oct 20;58(84):11762-11782. doi: 10.1039/d2cc04541a.
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Novel 2-Aryloxazoline Compounds Exhibit an Inhibitory Effect on spp., Including Antifungal-Resistant Isolates.新型2-芳基恶唑啉化合物对包括耐真菌分离株在内的 spp. 表现出抑制作用。
ACS Med Chem Lett. 2020 Nov 23;11(12):2470-2475. doi: 10.1021/acsmedchemlett.0c00449. eCollection 2020 Dec 10.
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Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors.受自然启发的分子设计：用于高效HIV-1蛋白酶抑制剂的双环和多环醚的立体选择性合成
Asian J Org Chem. 2018 Aug;7(8):1448-1466. doi: 10.1002/ajoc.201800255. Epub 2018 Jun 8.
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Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.新型HIV-1蛋白酶抑制剂的设计：引入间苯二甲酰胺衍生的P2-P3配体、抑制剂-HIV-1蛋白酶复合物的合成、生物学评价及X射线结构研究
Bioorg Med Chem. 2017 Oct 1;25(19):5114-5127. doi: 10.1016/j.bmc.2017.04.005. Epub 2017 Apr 9.
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Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability.解决萨尔文诺林A中A环的结构灵活性问题：发现一种具有增强代谢稳定性的强效κ-阿片受体激动剂。
J Med Chem. 2017 May 11;60(9):3866-3878. doi: 10.1021/acs.jmedchem.7b00148. Epub 2017 Apr 19.
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Cu(II)-catalyzed olefin migration and Prins cyclization: highly diastereoselective synthesis of substituted tetrahydropyrans.Cu(II)催化的烯烃迁移和 Prins 环化：取代的四氢吡喃的高度非对映选择性合成。
Org Lett. 2011 Aug 19;13(16):4328-31. doi: 10.1021/ol2016675. Epub 2011 Jul 28.
本文引用的文献
1
Ester derived titanium enolate aldol reaction: chelation controlled diastereoselective synthesis of -aldols.酯衍生的烯醇钛醛醇缩合反应：螯合控制的非对映选择性合成β-羟醛。
Tetrahedron Lett. 2001 Feb 12;42(7):1227-1231. doi: 10.1016/S0040-4039(00)02227-9. Epub 2001 Feb 28.
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TiC1 promoted three component coupling reaction: an efficient method for the substituted tetrahydropyrilidene acetates.TiC1促进的三组分偶联反应：一种合成取代四氢吡啶亚基乙酸酯的有效方法。
Tetrahedron Lett. 1999 Jun 25;40(26):4751-4754. doi: 10.1016/S0040-4039(99)00811-4. Epub 1999 Jul 29.
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A macrolactonization-based strategy to obtain microtuble-stabilizing agent (-)-laulimalide.一种基于大环内酯化的策略，用于获得微管稳定剂（-）-劳利霉素。
Tetrahedron Lett. 2001 May 14;42(20):3399-3401. doi: 10.1016/S0040-4039(01)00436-1. Epub 2001 Apr 25.
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-Symmetric chiral bis(oxazoline)-metal complexes in catalytic asymmetric synthesis.催化不对称合成中的对称手性双（恶唑啉）-金属配合物
Tetrahedron Asymmetry. 1998 Jan 16;9(1):1-45. doi: 10.1016/S0957-4166(97)00593-4.
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Bis(oxazoline) derived cationic aqua complexes: highly effective catalysts for enantioselective Diels-Alder reactions.双（恶唑啉）衍生的阳离子水合配合物：对映选择性狄尔斯-阿尔德反应的高效催化剂。
Tetrahedron Asymmetry. 1998 Oct 23;9(20):3687-3691. doi: 10.1016/S0957-4166(98)00362-0. Epub 2000 Jun 15.
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A stereoselective synthesis of (+)-boronolide.（+）-硼内酯的立体选择性合成。
Tetrahedron Lett. 2000 Feb 12;41(7):1003-1006. doi: 10.1016/S0040-4039(99)02246-7. Epub 2000 Jun 22.
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Asymmetric Syntheses of Potent Antitumor Macrolides Cryptophycin B and Arenastatin A.强效抗肿瘤大环内酯类化合物隐藻素B和阿雷他汀A的不对称合成
European J Org Chem. 2004 May;2004(10):2131-2141. doi: 10.1002/ejoc.200300814. Epub 2004 Apr 27.
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Synthesis of Bioactive Natural Products by Asymmetric - and -Aldol Reactions.通过不对称羟醛缩合反应合成生物活性天然产物
Synthesis (Stuttg). 2009 Sep;2009(17):2992-3002. doi: 10.1055/s-0029-1216941.
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Design of Potent Inhibitors for Human Brain Memapsin 2 (-Secretase).人脑海马型天冬氨酸蛋白酶2（β-分泌酶）强效抑制剂的设计
J Am Chem Soc. 2000 Apr 12;122(14):3522-3523. doi: 10.1021/ja000300g. Epub 2000 Mar 23.
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TiCl Promoted Three Component Coupling Reaction : A New Method for the Synthesis of Functionalized Tetrahydrofurans and Tetrahydropyrans.四氯化钛促进的三组分偶联反应：一种合成官能化四氢呋喃和四氢吡喃的新方法。
Tetrahedron Lett. 1999 Feb 5;40(6):1083-1086. doi: 10.1016/S0040-4039(98)02633-1.
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