通过不对称多组分反应高非对映选择性合成修饰核苷。
Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction.
机构信息
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.
出版信息
Chem Commun (Camb). 2010 Feb 28;46(8):1218-20. doi: 10.1039/b924807b. Epub 2010 Jan 25.
Abstract
We have developed a practical synthesis of unique nucleoside derivatives via TiCl(4) promoted multicomponent reaction of optically active dihydrofuran, ethyl pyruvate/glyoxylate, and a TMS protected nucleobase in a single-pot operation.
摘要
我们开发了一种通过 TiCl(4) 促进的具有光学活性的二氢呋喃、丙酮酸乙酯/乙醛酸和 TMS 保护的核苷碱基的多组分反应在单锅中进行独特核苷衍生物的实用合成方法。
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