不对称多组分反应：取代吡咯烷和脯氨酸的非对映选择性合成
Asymmetric multicomponent reactions: diastereoselective synthesis of substituted pyrrolidines and prolines.
作者信息
Ghosh Arun K, Kulkarni Sarang, Xu Chun-Xiao, Fanwick Phillip E
机构信息
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
出版信息
Org Lett. 2006 Sep 28;8(20):4509-11. doi: 10.1021/ol061672i.
Abstract
A novel diastereoselective synthesis of substituted pyrrolidines has been developed. Asymmetric multicomponent reactions of optically active phenyldihydrofuran, N-tosyl imino ester, and silane reagents in a one-pot operation afforded highly substituted pyrrolidine derivatives diastereoselectively. The reaction is quite efficient and constructed up to three stereogenic centers in a single operation.
摘要
已开发出一种新颖的取代吡咯烷的非对映选择性合成方法。光学活性苯基二氢呋喃、N-甲苯磺酰基亚氨基酯和硅烷试剂在一锅操作中的不对称多组分反应以非对映选择性方式提供了高度取代的吡咯烷衍生物。该反应非常高效，并且在一次操作中构建了多达三个立体中心。
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