[儿童缺铁性贫血伴反复呼吸道感染的细胞免疫]
[Cellular immunity in childhood iron deficiency anemia with recurrent respiratory infections].
作者信息
Liu W, Jiang A, Guo C
机构信息
PLA No. 60 Hospital, Yunnan Dali 671003.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 1997 Nov;18(11):566-7.
OBJECTIVE
To examine interleukin-2 (IL-2) activity,serum soluble IL-2 receptor (sIL-2R) level and T lymphocyte subsets in peripheral blood from 63 childhood iron deficiency anemia (IDA) patients with recurrent respiratory infections(RRI).
METHODS
IL-2 activity, sIL-2R level and T lymphocyte subsets were assayed by MTT, ELISA and APAAP, respectively.
RESULTS
IL-2 activity, percentages of CD3+ and CD4+ cells as well as the ratio of CD4+/ CD8+ cells in the patients were significantly lower ( P < 0.01),while sIL-2R levels were higher than that in normal controls (P < 0.01). No significant change was found in the percentage of CD8+ cells.
CONCLUSION
Cellular immunity was impaired in childhood IDA with RRI.
目的
检测63例患有反复呼吸道感染（RRI）的儿童缺铁性贫血（IDA）患者外周血中的白细胞介素-2（IL-2）活性、血清可溶性IL-2受体（sIL-2R）水平及T淋巴细胞亚群。
方法
分别采用MTT法、ELISA法及APAAP法检测IL-2活性、sIL-2R水平及T淋巴细胞亚群。
结果
患者的IL-2活性、CD3⁺和CD4⁺细胞百分比以及CD4⁺/CD8⁺细胞比值均显著降低（P<0.01），而sIL-2R水平高于正常对照组（P<0.01）。CD8⁺细胞百分比未发现明显变化。
结论
患有RRI的儿童IDA患者的细胞免疫功能受损。
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