Tekwani B L, Stanley B A, Pegg A E
Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033.
Biochim Biophys Acta. 1992 Mar 24;1130(2):221-3. doi: 10.1016/0167-4781(92)90533-6.
The nucleotide sequence of a cDNA encoding the proenzyme of hamster S-adenosylmethionine decarboxylase including 169 nucleotides of the 5' untranslated region has been determined. The deduced amino acid sequence shows a remarkable similarity to the human proenzyme with only seven differences out of 334 amino acids. The nucleotide sequence of the 5' untranslated region showed 93% homology with the corresponding rat and human sequences suggesting that this region may play an important role in the regulation of S-adenosylmethionine decarboxylase expression.
已确定编码仓鼠S-腺苷甲硫氨酸脱羧酶原酶的cDNA的核苷酸序列，其中包括5'非翻译区的169个核苷酸。推导的氨基酸序列与人类原酶显示出显著的相似性，在334个氨基酸中只有7个差异。5'非翻译区的核苷酸序列与相应的大鼠和人类序列显示出93%的同源性，表明该区域可能在S-腺苷甲硫氨酸脱羧酶表达的调节中起重要作用。
