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Advances in the study of SR protein family.

作者信息

Ma Xiaoyun, He Fuchu

机构信息

Beijing Institute of Radiation Medicine, Beijing 100850, China.

出版信息

Genomics Proteomics Bioinformatics. 2003 Feb;1(1):2-8. doi: 10.1016/s1672-0229(03)01002-7.

DOI:10.1016/s1672-0229(03)01002-7
PMID:15626328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5172405/
Abstract

The name of SR proteins is derived from their typical RS domain that is rich in serine (Ser, S) and arginine (Arg, R). They are conserved in evolution. Up to now, 10 members of the SR protein family have been identified in humans. SR proteins contain one or two RNA binding motifs aside from the RS domain, and also possess special biochemical and immunological features. As to the functions of SR proteins, they facilitate the recruitment of the components of splicesome via protein-protein interaction to prompt the assembly of early splicesome; while in alternative splicing, tissue-specifically expressed SR protein along with the relative ratio of SR protein and heterogeneous nuclear ribonucleoprotein (hnRNP) is composed of two main regulative mechanisms to alternative splicing. Almost all of the biochemical functions are regulated by reversible phosphorylation.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c3/5172405/e2722c9bc944/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c3/5172405/28e0cb104189/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c3/5172405/e2722c9bc944/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c3/5172405/28e0cb104189/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c3/5172405/e2722c9bc944/gr2.jpg

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Cancer Res. 2001 Sep 15;61(18):6876-84.
2
Regulation of SR protein localization during development.发育过程中SR蛋白定位的调控。
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10184-9. doi: 10.1073/pnas.181340498.
3
SC35 plays a role in T cell development and alternative splicing of CD45.SC35在T细胞发育及CD45的可变剪接过程中发挥作用。
Genes (Basel). 2022 Sep 16;13(9):1659. doi: 10.3390/genes13091659.
4
Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting.基于大规模和高分辨率质谱的蛋白质组学分析为治疗靶点定义了食管癌的分子亚型。
Nat Commun. 2021 Aug 16;12(1):4961. doi: 10.1038/s41467-021-25202-5.
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HIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase.HIV-1反式激活蛋白通过上调双重特异性酪氨酸磷酸化调节激酶1A抑制SC35介导的Tau外显子10包含。
J Biol Chem. 2015 Dec 25;290(52):30931-46. doi: 10.1074/jbc.M115.675751. Epub 2015 Nov 3.
6
Molecular anatomy of a speckle.斑点的分子解剖结构。
Anat Rec A Discov Mol Cell Evol Biol. 2006 Jul;288(7):664-75. doi: 10.1002/ar.a.20336.
Mol Cell. 2001 Feb;7(2):331-42. doi: 10.1016/s1097-2765(01)00181-2.
4
Regulation of alternative splicing of CD45 by antagonistic effects of SR protein splicing factors.SR蛋白剪接因子的拮抗作用对CD45可变剪接的调控
J Immunol. 2000 May 15;164(10):5287-95. doi: 10.4049/jimmunol.164.10.5287.
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6
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8
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