Wang Wenqing, Fujiwara Sakuhei, Seguchi Shun-ichiro, Yokoyama Shigeo, Mizoguchi Masako
Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University, 1 Idaigaoka, Hasama, Oita 879-5593, Japan.
J Dermatol. 2004 Sep;31(9):752-5. doi: 10.1111/j.1346-8138.2004.tb00590.x.
A 28-year-old Japanese woman was referred to us because of widespread bilateral blue-gray and brown pigmentation on her face. Pigmentation was apparant on both sclerae, the alae of the nose, the lower lip and the gingiva; and it was also evident on her extremities. A biopsy specimen revealed melanin-containing cells and numerous mononulear cells in the upper dermis, particularly, near the small vessels. The melanin-containing cells immunoreacted with S100-specific antibodies but did not react with CD68-specific antibodies, these observations indicated that they were melanocytes. A diagnosis was made of acquired dermal melanocytosis (ADM), even though ADM is very rarely associated with conjunctival and mucosal involvement. Dermal melanocytes and large numbers of mononuclear cells adjacent to small vessels in the upper dermis have not previously been reported in ADM. Such melanocytes might play an important role in protecting blood cells from ultraviolet light. The presence of mononuclear cells close to melanocytes suggests that an inflammatory reaction might have initiated the activation of these dermal melanocytes.
一名28岁的日本女性因面部广泛的双侧蓝灰色和棕色色素沉着被转诊至我院。色素沉着出现在双侧巩膜、鼻翼、下唇和牙龈；在其四肢也很明显。活检标本显示真皮上层有含黑色素细胞和大量单核细胞，特别是在小血管附近。含黑色素细胞与S100特异性抗体发生免疫反应，但不与CD68特异性抗体反应，这些观察表明它们是黑素细胞。尽管获得性皮肤黑素细胞增多症（ADM）很少伴有结膜和黏膜受累，但仍做出了ADM的诊断。真皮上层小血管附近的真皮黑素细胞和大量单核细胞此前在ADM中尚未见报道。此类黑素细胞可能在保护血细胞免受紫外线照射方面发挥重要作用。靠近黑素细胞的单核细胞的存在表明炎症反应可能引发了这些真皮黑素细胞的激活。
