Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Red Brick Dermatology Clinic, Sapporo, Japan.
Clin Exp Dermatol. 2018 Oct;43(7):806-809. doi: 10.1111/ced.13546. Epub 2018 Jun 27.
Acquired dermal melanocytosis of the face and extremities (ADMFE) is an unusual form of acquired dermal melanocytosis (ADM). In this paper, we report a case of ADMFE and review the published literature. Our review highlights several clinical differences between ADMFE and ADM: (i) more frequent involvement of the nasal alae in ADMFE than in ADM, (ii) less frequent involvement of the cheeks in ADMFE than in ADM, (iii) limbs affected in all cases of ADMFE but in few cases of ADM, and (iv) frequent involvement of conjunctiva and/or gingiva in ADMFE but very rare involvement in ADM. These findings strongly support the hypothesis that ADMFE is clinically distinct from the classic form of ADM, and gaining an understanding of its phenotype will enable accurate diagnosis and early intervention by Q-switched laser therapy, which should benefit those patients with disease-related cosmetic issues.
获得性面部和四肢真皮黑色素沉着症（ADMFE）是一种不常见的获得性真皮黑色素沉着症（ADM）。本文报告了一例 ADMFE 病例，并复习了已发表的文献。我们的综述强调了 ADMFE 和 ADM 之间的几个临床差异：（i）ADMFE 累及鼻翼的频率高于 ADM，（ii）ADMFE 累及面颊的频率低于 ADM，（iii）ADMFE 累及所有四肢，而累及 ADM 的四肢较少，（iv）ADMFE 累及结膜和/或牙龈的频率较高，而累及 ADM 的频率非常低。这些发现强烈支持 ADMFE 在临床上与经典型 ADM 不同的假说，了解其表型将有助于通过 Q 开关激光治疗进行准确诊断和早期干预，这将使那些因疾病导致美容问题的患者受益。
