孪生山羊自发性眼鳞状细胞癌：病理及生物分子研究

Spontaneous ocular squamous cell carcinoma in twin goats: pathological and biomolecular studies.

作者信息

Marà M, Di Guardo G, Venuti A, Marruchella G, Palmieri C, De Rugeriis M, Petrizzi L, Simeone P, Rizzo C, Della Salda L

机构信息

Department of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy.

出版信息

J Comp Pathol. 2005 Jan;132(1):96-100. doi: 10.1016/j.jcpa.2004.06.007.

DOI:10.1016/j.jcpa.2004.06.007

PMID:15629484

Abstract

Ocular squamous cell carcinoma (OSCC) is a well-characterized tumour occurring spontaneously in cattle and other mammalian species but not previously reported in the goat. This report describes the histological features of well-differentiated OSCCs in twin goats. Biomolecular investigations led to the identification of Papillomavirus-related DNA sequences within the neoplastic ocular parenchyma of both animals, but immunohistochemical and ultrastructural studies failed to demonstrate viral particles. A putative role of Papillomavirus in the aetiology of OSCC is discussed, together with other possible causative factors.

摘要

眼鳞状细胞癌（OSCC）是一种在牛和其他哺乳动物物种中自然发生且特征明确的肿瘤，但此前在山羊中未见报道。本报告描述了一对孪生山羊中高分化OSCC的组织学特征。生物分子研究在两只动物的肿瘤性眼实质内鉴定出了乳头瘤病毒相关的DNA序列，但免疫组织化学和超微结构研究未能证实病毒颗粒的存在。文中讨论了乳头瘤病毒在OSCC病因学中的潜在作用以及其他可能的致病因素。