Dreyfus Jennifer, Schobert Charles S, Dubielzig Richard R
Comparative Ocular Pathology Laboratory of Wisconsin, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706-1102, USA.
Vet Ophthalmol. 2011 May;14(3):161-8. doi: 10.1111/j.1463-5224.2010.00858.x.
Canine corneal squamous cell carcinoma (SCC) is a rare tumor, with only eight cases previously published in the veterinary literature. The Comparative Ocular Pathology Lab of Wisconsin (COPLOW) has diagnosed 26 spontaneously occurring cases, 23 in the past 4 years. This retrospective study describes age and breed prevalence, concurrent therapy, biologic behavior, tumor size and character, and 6-month survival rates after diagnosis.
A search of the COPLOW database identified 26 corneal SCC cases diagnosed from 1978 to 2008. There is a strong breed predilection (77%) in brachycephalic breeds, particularly those prone to keratoconjunctivitis sicca. The mean age was 9.6 years (range 6-14.5 years). Follow-up information >6 months was available for 15 of 26 cases. Recurrence occurred in the same eye in nine cases, seven of which were incompletely excised at the time of first keratectomy. No cases were known to have tumor growth in the contralateral eye and no cases of distant metastases are known. Where drug history is known, 16 of 21 dogs had a history of treatment with topical immunosuppressive therapy (cyclosporine or tacrolimus) at the time of diagnosis.
Chronic inflammatory conditions of the cornea and topical immunosuppressive therapy may be risk factors for developing primary corneal SCC in dogs. SCC should be considered in any differential diagnosis of corneal proliferative lesions. Superficial keratectomy with complete excision is recommended, and the metastatic potential appears to be low.
犬角膜鳞状细胞癌（SCC）是一种罕见肿瘤，兽医文献中此前仅发表过8例。威斯康星比较眼病理实验室（COPLOW）已诊断出26例自发性病例，其中23例是在过去4年中诊断出的。这项回顾性研究描述了年龄和品种患病率、同期治疗、生物学行为、肿瘤大小和特征以及诊断后的6个月生存率。
对COPLOW数据库的检索确定了1978年至2008年诊断出的26例角膜SCC病例。短头品种有强烈的品种偏好（77%），特别是那些易患干眼症的品种。平均年龄为9.6岁（范围6 - 14.5岁）。26例中有15例可获得>6个月的随访信息。9例在同一只眼中复发，其中7例在首次角膜切除术时切除不完全。已知没有病例对侧眼出现肿瘤生长，也没有远处转移的病例。在已知用药史的情况下，21只犬中有16只在诊断时有局部免疫抑制治疗（环孢素或他克莫司）的治疗史。
角膜的慢性炎症状态和局部免疫抑制治疗可能是犬原发性角膜SCC发生的危险因素。在角膜增生性病变的任何鉴别诊断中都应考虑SCC。建议进行彻底切除的浅表角膜切除术，且转移潜能似乎较低。
