Kalach Nicolas, Mention Karine, Guimber Dominique, Michaud Laurent, Spyckerelle Claire, Gottrand Fréderic
Department of Pediatrics, Clinique de Pédiatrie Saint Antoine, Hôpital Saint Vincent de Paul, Catholic University, Boulevard Belfort, BP 387, 59020 Lille, France.
Pediatrics. 2005 Jan;115(1):17-21. doi: 10.1542/peds.2004-0131.
To assess symptoms associated with Helicobacter pylori infection in children presenting with nonulcer dyspepsia (NUD).
A prospective double-blind study was conducted between March 2001 and April 2002 in children at least 6 years old with NUD who had been referred for upper gastrointestinal endoscopy for epigastric pain. A standardized questionnaire was administered blindly by a pediatric gastroenterologist. This questionnaire characterized epigastric pain and associated factors. Infection was confirmed by positive culture and histologic examination of the gastric mucosa.
From 100 children enrolled, 26 proved infected (12 female, 14 male; mean age: 11.4 +/- 2.6 years), and 74 were noninfected (44 female, 30 male; mean age: 10.4 +/- 3.1 years). There were no differences in age or symptom characteristics between groups except for epigastric pain during meals that was more frequent in noninfected than in infected children (25.6% vs 3.8%).
There were no specific characteristics of symptoms in nonulcer-dyspeptic H pylori-infected children as compared with noninfected children.
评估患有非溃疡性消化不良（NUD）的儿童幽门螺杆菌感染相关症状。
2001年3月至2002年4月，对至少6岁、因上腹部疼痛而接受上消化道内镜检查的NUD儿童进行了一项前瞻性双盲研究。由儿科胃肠病学家盲目发放一份标准化问卷。该问卷对腹痛及相关因素进行了描述。通过胃黏膜培养阳性和组织学检查确诊感染。
在纳入的100名儿童中，26名被证实感染（12名女性，14名男性；平均年龄：11.4±2.6岁），74名未感染（44名女性，30名男性；平均年龄：10.4±3.1岁）。除了未感染儿童进餐时上腹部疼痛比感染儿童更频繁（25.6%对3.8%）外，两组在年龄或症状特征上没有差异。
与未感染儿童相比，幽门螺杆菌感染的非溃疡性消化不良儿童没有特定的症状特征。
