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持续关注孕烷X受体：一个可能并非仅对骨骼有破坏作用的“孤儿”角色。

Stay tuned to PXR: an orphan actor that may not be D-structive only to bone.

作者信息

Holick Michael F

机构信息

Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

出版信息

J Clin Invest. 2005 Jan;115(1):32-4. doi: 10.1172/JCI23995.

DOI:10.1172/JCI23995
PMID:15630441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC539210/
Abstract

Pregnane X receptor (PXR) plays an important role in detoxifying xenobiotics and drugs. In this issue of the JCI, Pascussi et al. provide convincing evidence that PXR can also induce vitamin D deficiency and bone disease because of its ability to cross-talk with the vitamin D-responsive gene that catabolizes 25-hydroxy-vitamin D and 1,25-dihydroxyvitamin D. This cross-talk behavior has important health ramifications and can be mitigated through the identification and treatment of PXR-induced vitamin D deficiency.

摘要

孕烷X受体（PXR）在对外源化学物质和药物进行解毒过程中发挥着重要作用。在本期《临床研究杂志》中，帕斯库西等人提供了令人信服的证据，表明PXR还可导致维生素D缺乏和骨病，因为它能够与分解代谢25-羟基维生素D和1,25-二羟基维生素D的维生素D反应基因发生相互作用。这种相互作用行为具有重要的健康影响，可通过识别和治疗PXR诱导的维生素D缺乏来减轻。

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2
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