McGrath J
Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Wacol, Queensland, Australia.
Med Hypotheses. 2001 Mar;56(3):367-71. doi: 10.1054/mehy.2000.1226.
Hypovitaminosis D is a candidate risk-modifying factor for a diverse range of disorders apart from rickets and osteoporosis. Based on epidemiology, and on in vitro and animal experiment, vitamin D has been linked to multiple sclerosis, certain cancers (prostate, breast and colorectal), insulin-dependent diabetes mellitus and schizophrenia. I hypothesise that low pre- and perinatal vitamin D levels imprint on the functional characteristics of various tissues throughout the body, leaving the affected individual at increased risk of developing a range of adult-onset disorders. The hypothesis draws from recent advances in our understanding of the early origin of adult disease and proposes a 'critical window' during which vitamin D levels may have a persisting impact on adult health outcomes. Methods to test the hypothesis are outlined. If correct, the hypothesis has important implications for public health. Careful attention to maternal vitamin D status could translate into diverse improvements in health outcomes for the following generation.
除佝偻病和骨质疏松症外，维生素D缺乏是多种疾病潜在的风险修正因素。基于流行病学以及体外和动物实验，维生素D已被证实与多发性硬化症、某些癌症（前列腺癌、乳腺癌和结直肠癌）、胰岛素依赖型糖尿病和精神分裂症有关。我推测，围产期维生素D水平低会影响全身各组织的功能特性，使个体成年后患一系列疾病的风险增加。这一推测源于我们对成人疾病早期起源认识的最新进展，并提出了一个“关键窗口期”，在此期间维生素D水平可能会对成人健康产生持续影响。文中概述了验证该推测的方法。如果这一推测正确，将对公共卫生具有重要意义。密切关注母亲的维生素D状况可能会给下一代的健康带来多方面的改善。
