Hjelm U, Kaustová J, Kubín M, Hoffner S E
Department of Bacteriology, National Bacteriological Laboratory, Stockholm, Sweden.
Eur J Clin Microbiol Infect Dis. 1992 Jan;11(1):51-4. doi: 10.1007/BF01971272.
The susceptibility of Mycobacterium kansasii to antibacterial agents alone and in combination was studied. Widespread resistance to ethambutol, ciprofloxacin and isoniazid was found when these drugs were tested separately. However, pronounced antibacterial effects were seen when ethambutol was tested in combination with ciprofloxacin, rifampicin or rifabutin, which corresponded to significantly decreased resistance to these drugs in combination.
研究了堪萨斯分枝杆菌对单独及联合抗菌药物的敏感性。当分别测试乙胺丁醇、环丙沙星和异烟肼时，发现对这些药物普遍存在耐药性。然而，当乙胺丁醇与环丙沙星、利福平或利福布汀联合测试时，观察到显著的抗菌效果，这与联合使用这些药物时耐药性显著降低相对应。
