Grimsdottir M R, Hensten-Pettersen A, Kullmann A
NIOM, Scandinavian Institute of Dental Materials, University of Oslo, Norway.
Eur J Orthod. 1992 Feb;14(1):47-53. doi: 10.1093/ejo/14.1.47.
The use of orthodontic appliances may contribute to local gingivitis, often attributed to increased plaque retention. Gingivitis of bacterial origin cannot clinically be distinguished from local tissue irritation caused by corrosion products. The purpose of this investigation was to assess the cytotoxic effect of various metallic components used in orthodontics. Multicomponent devices such as facebows, molar bands, and brackets along with single-component brackets and archwires were tested by the agar overlay cytotoxicity test with mouse fibroblast cells. None of the archwires caused any cytotoxic effect, even though some contained 54 per cent nickel. However, the multi-component devices, which were joined with silver- and copper-based brazing alloys were more cytotoxic than the single-component devices. Copper is more cytotoxic than nickel, which could explain the greater cytotoxic effect of the samples with brazing materials. It is speculated that cytotoxic corrosion products from orthodontic appliances might contribute to localized gingivitis.
正畸矫治器的使用可能会导致局部牙龈炎，这通常归因于菌斑滞留增加。临床上，细菌性牙龈炎与由腐蚀产物引起的局部组织刺激无法区分。本研究的目的是评估正畸中使用的各种金属成分的细胞毒性作用。通过琼脂覆盖细胞毒性试验，使用小鼠成纤维细胞对诸如面弓、磨牙带和托槽等多部件装置以及单部件托槽和弓丝进行了测试。即使有些弓丝含有54%的镍，也没有引起任何细胞毒性作用。然而，与银基和铜基钎焊合金连接的多部件装置比单部件装置的细胞毒性更大。铜比镍的细胞毒性更大，这可以解释含有钎焊材料的样品具有更大细胞毒性作用的原因。据推测，正畸矫治器产生的细胞毒性腐蚀产物可能会导致局部牙龈炎。
