Heacock Patricia M, Hertzler Steven R, Williams Jennifer A, Wolf Bryan W
Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, USA.
J Am Diet Assoc. 2005 Jan;105(1):65-71. doi: 10.1016/j.jada.2004.11.001.
To determine the effect of different doses of Salacia oblonga extract, an herbal alpha-glucosidase inhibitor, on postprandial glycemic, insulinemic, and breath hydrogen responses in healthy adults.
Double-masked, randomized crossover design.
Subjects, after fasting for 12 hours, consumed four test meals consisting of 480 mL of study beverage (14 g fat, 82 g carbohydrate, and 20 g protein) with 0, 500, 700, or 1,000 mg of S oblonga extract on four separate occasions. Capillary finger-prick plasma glucose and venous serum insulin concentrations were measured at baseline and for 2 hours postprandially. Breath hydrogen excretion was measured at baseline and hourly for 8 hours postprandially.
SUBJECTS/SETTING: Thirty-nine healthy, nondiabetic adults (body mass index=23.7+/-0.4, age=25.7+/-0.9 years.
Repeated-measures analysis of variance was applied to the raw data or data that had been transformed (log, rank) when necessary due to nonnormality. The Tukey-Kramer post hoc test was used for pairwise comparisons.
Compared with the control, the 1,000-mg S oblonga extract dose reduced the plasma glucose and serum insulin incremental areas under the curve (0 to 120 minutes postprandial) by 23% ( P =.32) and 29% ( P =.01), respectively. The other doses of S oblonga extract did not impact glycemia or insulinemia. Breath hydrogen excretion increased linearly as the dose of S oblonga extract was advanced.
The presence of S oblonga extract tended to lower postprandial glycemia and significantly reduced the postprandial insulin response. The increase in breath hydrogen excretion suggests a mechanism similar to prescription alpha-glucosidase inhibitors. Future studies of S oblonga extract in patients with diabetes are needed.
确定不同剂量的长柄匙羹藤提取物（一种草药α-葡萄糖苷酶抑制剂）对健康成年人餐后血糖、胰岛素水平及呼出气氢气反应的影响。
双盲、随机交叉设计。
受试者禁食12小时后，在四个不同时间分别食用四份测试餐，每份测试餐包含480毫升研究饮料（14克脂肪、82克碳水化合物和20克蛋白质），分别添加0、500、700或1000毫克的长柄匙羹藤提取物。在基线及餐后2小时测量毛细血管指尖血糖和静脉血清胰岛素浓度。在基线及餐后8小时每小时测量呼出气氢气排泄量。
受试者/研究地点：39名健康的非糖尿病成年人（体重指数=23.7±0.4，年龄=25.7±0.9岁）。
对原始数据或因数据不呈正态分布而在必要时进行转换（对数、秩转换）的数据应用重复测量方差分析。采用Tukey-Kramer事后检验进行两两比较。
与对照组相比，1000毫克长柄匙羹藤提取物剂量使餐后曲线下血浆葡萄糖和血清胰岛素增量面积（餐后0至120分钟）分别降低了23%（P=0.32）和29%（P=0.01）。其他剂量的长柄匙羹藤提取物对血糖或胰岛素血症无影响。随着长柄匙羹藤提取物剂量增加，呼出气氢气排泄呈线性增加。
长柄匙羹藤提取物有降低餐后血糖的趋势，并显著降低餐后胰岛素反应。呼出气氢气排泄增加提示其作用机制与处方α-葡萄糖苷酶抑制剂相似。需要对糖尿病患者进行长柄匙羹藤提取物的进一步研究。
