A-503083 A、B、E和F，由链霉菌属SANK 62799产生的新型细菌转位酶I抑制剂。

A-503083 A, B, E and F, novel inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 62799.

作者信息

Muramatsu Yasunori, Ohnuki Takashi, Ishii Michiko Miyazawa, Kizuka Masaaki, Enokita Ryuzo, Miyakoshi Shunichi, Takatsu Toshio, Inukai Masatoshi

机构信息

Lead Discovery Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

出版信息

J Antibiot (Tokyo). 2004 Oct;57(10):639-46. doi: 10.7164/antibiotics.57.639.

DOI:10.7164/antibiotics.57.639

PMID:15638324

Abstract

Novel nucleoside antibiotics were isolated from the cultured broth of the strain classified as Streptomyces sp. SANK 62799. The strain produced four novel capuramycin derivatives designated as A-503083 A, B, E and F. Their structures were elucidated as 2'-O-carbamoyl derivatives of A-500359 A, B (capuramycin), E and F, respectively. A-503083 A, B, E and F inhibited bacterial phospho-N-acetylmuramyl-pentapeptide-translocase (translocase I: EC 2.7.8.13) with IC50 values of 0.024, 0.038, 0.135 and 17.9 microM, respectively.

摘要

从分类为链霉菌属SANK 62799菌株的培养肉汤中分离出新型核苷类抗生素。该菌株产生了四种新型卡普霉素衍生物，命名为A-503083 A、B、E和F。它们的结构分别被鉴定为A-500359 A、B（卡普霉素）、E和F的2'-O-氨基甲酰基衍生物。A-503083 A、B、E和F对细菌磷酸-N-乙酰胞壁酰-五肽转位酶（转位酶I：EC 2.7.8.13）具有抑制作用，IC50值分别为0.024、0.038、0.135和17.9微摩尔。