Lead Discovery and Optimization Research Laboratories I, Daiichi Sankyo Co. Ltd, Tokyo, Japan.
J Antibiot (Tokyo). 2011 Jul;64(7):495-501. doi: 10.1038/ja.2011.38. Epub 2011 May 18.
During the course of screening for translocase I inhibitors, the new liposidomycin-related compounds, A-90289 A and B, were isolated from a culture broth of Streptomyces sp. SANK 60405. The structural elucidations were carried out by NMR and high-resolution mass spectral analyses, and they were classified as members of the liponucleoside antibiotics group with a sulfate group at the C-2' position. A-90289 A and B inhibited bacterial translocase I with IC(50) values of 36.5 ng ml(-1) and 33.8 ng ml(-1), respectively.
在筛选转位酶 I 抑制剂的过程中，从链霉菌 SANK 60405 的发酵液中分离到了新型脂多霉素相关化合物 A-90289A 和 B。通过 NMR 和高分辨率质谱分析进行了结构阐明，它们被归类为带有 C-2'位硫酸基团的脂核苷抗生素组的成员。A-90289A 和 B 对细菌转位酶 I 的抑制作用的 IC50 值分别为 36.5ng/ml 和 33.8ng/ml。
