基于结构的基因靶向发现螺旋霉素，一种细菌易位酶 I 抑制剂。
Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitor.
机构信息
Natural Product Research Group, Discovery Science and Technology Department, Drug Discovery and Biomedical Technology Unit, Daiichi Sankyo RD Novare Co., Ltd. Tokyo 134-8630 (Japan).
出版信息
Angew Chem Int Ed Engl. 2013 Oct 25;52(44):11607-11. doi: 10.1002/anie.201305546. Epub 2013 Sep 6.
Abstract
Rise and shine: Using a gene-targeting approach aimed at identifying potential L-threonine:uridine-5'-transaldolases that catalyze the formation of (5'S,6'S)-C-glycyluridine, a new bacterial translocase I inhibitor was discovered from an actinomycete following fermentation optimization.
摘要
起床了
通过一种基因靶向方法，旨在鉴定潜在的 L-苏氨酸：尿嘧啶-5'-转醛醇酶，该酶催化（5'S，6'S）-C-甘氨酰尿嘧啶的形成，一种新的细菌易位酶 I 抑制剂是在发酵优化后从放线菌中发现的。
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