Sorabjee J S, Garje R
Department of Medicine, Bombay Hospital Institute of Medical Sciences, 12 New Marine Lines, Bombay 400020, Maharashtra State, India.
Postgrad Med J. 2005 Jan;81(951):60-1. doi: 10.1136/pgmj.2004.018796.
Reactivation of pre-existing scars, as a manifestation of cutaneous sarcoidosis, is uncommon and the clinical significance of this odd symptom often remains unrecognised. In the appropriate setting a skin biopsy may serve to establish the diagnosis of sarcoidosis and avoid more invasive attempts at obtaining tissue. The case of a 72 year old man with remote reactivation of multiple cutaneous scars associated with a febrile illness, malaise, and hilar adenopathy is reported. A scar biopsy revealed multiple non-caseating granulomas and established the diagnosis of sarcoidosis. A short course of steroids was successful in causing regression of symptoms and cutaneous inflammation. Regression of inflammation in the scar provides a simple way to monitor response to treatment in this multisystem disease.
既往瘢痕再活化作为皮肤结节病的一种表现并不常见,这种奇特症状的临床意义常常未被认识。在合适的情况下,皮肤活检有助于确立结节病的诊断,并避免采用更具侵入性的方法获取组织。本文报告了一例72岁男性病例,其多个皮肤瘢痕出现远期再活化,并伴有发热性疾病、不适和肺门淋巴结病。瘢痕活检发现多个非干酪样肉芽肿,从而确立了结节病的诊断。短期使用类固醇成功使症状和皮肤炎症消退。瘢痕炎症的消退为监测这种多系统疾病的治疗反应提供了一种简单方法。