Rochester Mark A, LE Monnier Karena, Brewster Simon F
Department of Urology, Churchill Hospital, Oxford, United Kingdom.
J Urol. 2005 Feb;173(2):418-20. doi: 10.1097/01.ju.0000149872.35473.cb.
We evaluated the efficacy and tolerance of topical 0.2% glyceryl trinitrate (GTN) paste vs placebo to decrease pain associated with transrectal ultrasound guided prostate biopsy.
Between October 2003 and April 2004, 134 consecutive patients referred for a first prostate biopsy were randomized to receive topical 0.2% GTN paste or placebo 30 minutes prior to biopsy. Participants completed a 10 point visual analog pain score following the procedure.
Mean patient age was 68.5 years in the GTN group and 68.8 in the placebo group. There was a significant decrease in mean pain score in the GTN group compared with placebo (3.7 vs 4.8, p <0.05). Six patients (10%) in the GTN group complained of headache.
Topical GTN paste is an effective and well tolerated method of decreasing pain associated with transrectal ultrasound guided prostate biopsy. It is safe and easy to use, and it should be offered to patients undergoing this procedure.
我们评估了局部使用0.2%硝酸甘油（GTN）糊剂与安慰剂相比，在减轻经直肠超声引导下前列腺活检相关疼痛方面的疗效和耐受性。
在2003年10月至2004年4月期间，134例连续接受首次前列腺活检的患者被随机分为两组，在活检前30分钟分别接受局部0.2% GTN糊剂或安慰剂。参与者在活检后完成10分视觉模拟疼痛评分。
GTN组患者平均年龄为68.5岁，安慰剂组为68.8岁。与安慰剂组相比，GTN组的平均疼痛评分显著降低（3.7对4.8，p<0.05）。GTN组有6例患者（10%）抱怨头痛。
局部使用GTN糊剂是一种有效且耐受性良好的减轻经直肠超声引导下前列腺活检相关疼痛的方法。它安全易用，应提供给接受该手术的患者。
