Kidner Catherine A, Martienssen Robert A
Institute of Molecular Plant Sciences, Edinburgh University, EH9 3JR, UK.
Curr Opin Plant Biol. 2005 Feb;8(1):38-44. doi: 10.1016/j.pbi.2004.11.008.
MicroRNAs (miRNAs) are single-stranded RNA molecules of around 22 nucleotides (nt) in length that are associated with the RNA-induced silencing complex (RISC). They play an important role in plant development, either by targeting mRNA for cleavage or by inhibiting translation. Over the past year, the list of known miRNAs, confirmed targets and developmental effects has expanded, as has the realization that they are conserved during evolution and that small RNAs can play a direct role in cell-cell signaling.
微小RNA（miRNA）是长度约为22个核苷酸（nt）的单链RNA分子，与RNA诱导沉默复合体（RISC）相关。它们在植物发育中发挥重要作用，要么通过靶向mRNA进行切割，要么通过抑制翻译。在过去的一年里，已知的miRNA、已确认的靶标和发育效应的清单有所扩展，人们也认识到它们在进化过程中是保守的，并且小RNA可以在细胞间信号传导中发挥直接作用。
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