Spergel Jonathan M, Brown-Whitehorn Terri
Allergy Section, Division of Allergy and Immunology, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Wood 5, Philadelphia, PA 19104, USA.
Curr Allergy Asthma Rep. 2005 Jan;5(1):86-90. doi: 10.1007/s11882-005-0061-5.
Diagnosing food allergies can be challenging to the practitioner. Our armamentarium includes standardized skin prick testing, radioallergoimmunosorbent (RAST) testing, and food challenges. These methods have certainly been helpful in the IgE-mediated disorders, including urticaria and anaphylaxis. However, diagnosing patients who have the non-IgE (cell-mediated) or mixed (IgE and cell-mediated) disorders remains challenging with our current diagnostic methods. Recent studies have examined the use of patch testing for these food-allergic patients, specifically those with atopic dermatitis and eosinophilic esophagitis. In this article, we review literature regarding patch testing: its methods, its statistical usefulness, and its potential future role.
对从业者而言,诊断食物过敏颇具挑战性。我们的诊断方法包括标准化皮肤点刺试验、放射变应原吸附(RAST)试验以及食物激发试验。这些方法在诊断IgE介导的疾病,如荨麻疹和过敏反应方面确实很有帮助。然而,使用我们目前的诊断方法来诊断非IgE(细胞介导)或混合性(IgE和细胞介导)疾病的患者仍然具有挑战性。最近的研究探讨了斑贴试验在这些食物过敏患者中的应用,特别是那些患有特应性皮炎和嗜酸性食管炎的患者。在本文中,我们回顾了有关斑贴试验的文献:其方法、统计学效用以及其未来可能发挥的作用。