O'Rahilly Stephen, Barroso Inês, Wareham Nicholas J
University of Cambridge, Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
Science. 2005 Jan 21;307(5708):370-3. doi: 10.1126/science.1104346.
The intensive search for genetic variants that predispose to type 2 diabetes was launched with optimism, but progress has been slower than was hoped. Even so, major advances have been made in the understanding of monogenic forms of the disease which together represent a substantial health burden, and a few common gene variants that influence susceptibility have now been unequivocally identified. Armed with a better understanding of the tools needed to detect such genes, it seems inevitable that the rate of progress will increase and the relevance of genetic information to the diagnosis, treatment, and prevention of diabetes will become increasingly tangible.
对易患2型糖尿病的基因变异进行的深入研究在乐观情绪中展开，但进展比预期要慢。即便如此，在对该疾病单基因形式的理解方面已取得重大进展，单基因形式共同构成了相当大的健康负担，并且现已明确鉴定出一些影响易感性的常见基因变异。由于对检测此类基因所需工具的了解更加深入，进展速度似乎必然会加快，并且基因信息在糖尿病诊断、治疗和预防中的相关性将变得越来越切实可感。
