Hansen Torben
Steno Diabetes Center, Hagedorn Research Institute, Copenhagen, Denmark.
Ann Univ Mariae Curie Sklodowska Med. 2002;57(1):544-9.
Type 2 diabetes is a multifactorial disease caused by both oligo- and polygenic genetic factors as well as non-genetic factors that result from a lack of balance between the energy intake and output and other life style related factors. ADA and WHO have recently reclassified diabetes on both clinical stages and aetiological grounds. There is a lot of data related to the genetics of type 2 diabetes. However, many genes and gene products as well as their interactions with the environment at the molecular, cellular, tissue, and the whole organism levels are still unknown. Changes in the frequency of diabetes occurrence in various urban and rural populations and ethnic groups prove the relationship with the transition to the 'western' life style. Understanding of diabetes pathogenesis is essential to the development of new methods of treatment and strategies of effective prevention of this disease.
2型糖尿病是一种多因素疾病，由寡基因和多基因遗传因素以及非遗传因素引起，这些非遗传因素源于能量摄入与输出之间缺乏平衡以及其他与生活方式相关的因素。美国糖尿病协会（ADA）和世界卫生组织（WHO）最近基于临床阶段和病因对糖尿病进行了重新分类。有大量与2型糖尿病遗传学相关的数据。然而，许多基因和基因产物，以及它们在分子、细胞、组织和整个生物体水平上与环境的相互作用仍然未知。不同城乡人群和种族中糖尿病发病率的变化证明了其与向“西方”生活方式转变的关系。了解糖尿病发病机制对于开发新的治疗方法和有效预防该疾病的策略至关重要。
