Rizos Evangelos, Tambaki Afroditi P, Gazi Irene, Tselepis Alexandros D, Elisaf Moses
School of Medicine, Department of Internal Medicine, University of Ioannina, Dourouti Campus, 45110 Ioannina, Greece.
Prostaglandins Leukot Essent Fatty Acids. 2005 Mar;72(3):203-9. doi: 10.1016/j.plefa.2004.10.021.
Plasma- and lipoprotein-associated activity of the platelet activating factor acetylhydrolase (PAF-acetylhydrolase, PAF-AH) plays an important role in inflammation and in atherosclerotic process, which are present in the metabolic syndrome (MS). Paraoxonase 1 (PON1) is an esterase associated with high-density lipoprotein (HDL) which contributes to the anti-atherogenic effects of this lipoprotein. We investigated the activities of both enzymes in 60 patients with MS and 110 age- and sex-matched subjects without it (non-MS group). Plasma PAF-AH activity was higher in the MS compared to the non-MS group, while HDL-PAF-AH and serum PON1 activities were lower in the MS compared to the non-MS group. Univariate regression analysis in the MS group showed that plasma PAF-AH activity was positively associated with systolic blood pressure, whereas HDL-PAF-AH activity was inversely associated with the homeostasis model assessments (HOMA) index. Both associations remained significant in the multivariate regression analysis, suggesting that insulin resistance and systolic hypertension are major determinants for the alterations in plasma and HDL-associated PAF-AH activity among those observed in MS patients.
血小板活化因子乙酰水解酶（PAF - 乙酰水解酶，PAF - AH）的血浆和脂蛋白相关活性在炎症和动脉粥样硬化过程中起重要作用，而这些过程存在于代谢综合征（MS）中。对氧磷酶1（PON1）是一种与高密度脂蛋白（HDL）相关的酯酶，它有助于该脂蛋白的抗动脉粥样硬化作用。我们研究了60例MS患者和110例年龄及性别匹配的非MS患者（非MS组）中这两种酶的活性。与非MS组相比，MS组的血浆PAF - AH活性更高，而与HDL相关的PAF - AH和血清PON1活性在MS组中则更低。MS组的单变量回归分析表明，血浆PAF - AH活性与收缩压呈正相关，而HDL - PAF - AH活性与稳态模型评估（HOMA）指数呈负相关。在多变量回归分析中，这两种关联均保持显著，表明胰岛素抵抗和收缩期高血压是MS患者中观察到的血浆和HDL相关PAF - AH活性改变的主要决定因素。
