Kappert Kai, Peters Kevin G, Böhmer Frank D, Ostman Arne
Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institutet, 17176 Stockholm, Sweden.
Cardiovasc Res. 2005 Feb 15;65(3):587-98. doi: 10.1016/j.cardiores.2004.08.016.
Protein tyrosine phosphatases (PTPs) are critical regulators of cellular processes like migration, proliferation and differentiation that are involved in physiological and pathological vessel wall function. In this review, we summarize the biochemistry of this enzyme family, discuss the present knowledge concerning the identity and involvement of PTPs in vascular cells and in pathways of relevance to cardiovascular diseases. We also briefly introduce ongoing efforts to develop inhibitors of PTPs, and finally point to some opportunities for use of such agents in novel treatment strategies.
蛋白酪氨酸磷酸酶（PTPs）是细胞迁移、增殖和分化等细胞过程的关键调节因子，这些过程涉及生理和病理状态下的血管壁功能。在本综述中，我们总结了该酶家族的生物化学特性，讨论了目前关于PTPs在血管细胞以及与心血管疾病相关通路中的身份和作用的认识。我们还简要介绍了开发PTPs抑制剂的 ongoing efforts，并最后指出了在新型治疗策略中使用此类药物的一些机会。 （注：“ongoing efforts”直译为“正在进行的努力”，这里结合语境意译为“相关研究进展”可能更合适，但按要求保留原文未翻译完整的情况）
