Autiero Monica, De Smet Frederik, Claes Filip, Carmeliet Peter
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B-3000 Leuven, Belgium.
Cardiovasc Res. 2005 Feb 15;65(3):629-38. doi: 10.1016/j.cardiores.2004.09.013.
Despite the tremendous progress achieved in both vasculogenesis and angiogenesis in the last decade, little is still known about the molecular mechanisms underlying the pathfinding of blood vessels during their formation. However, emerging evidence shows that different axonal guidance cues, including members of the Slit and semaphorin families, are also involved in the blood vessel guidance, suggesting that blood vessels and nerves share common mechanisms in choosing and following specific paths to reach their respective targets. These promising findings open novel avenues not only in vascular biology but also in therapeutic angiogenesis. Indeed, the identification of new molecules involved in the guidance of blood vessels may be helpful in designing angiogenic strategies, which would insure both the formation of new blood vessels and their guidance into an organized and coordinated network.
尽管在过去十年中血管生成和血管新生方面取得了巨大进展，但对于血管形成过程中血管寻路的分子机制仍知之甚少。然而，新出现的证据表明，不同的轴突导向信号，包括Slit家族和信号素家族的成员，也参与血管导向，这表明血管和神经在选择和沿着特定路径到达各自目标方面具有共同机制。这些有前景的发现不仅为血管生物学，也为治疗性血管生成开辟了新途径。确实，识别参与血管导向的新分子可能有助于设计血管生成策略，这既能确保新血管的形成，又能将它们导向一个有组织、协调的网络。
