Kastrup Y, Le Grevès M, Nyberg F, Blomqvist A
Department of Biomedicine and Surgery, Faculty of Health Sciences, University of Linköping, S-581 85 Linköping, Sweden.
Neuroscience. 2005;130(2):419-25. doi: 10.1016/j.neuroscience.2004.10.003.
By using in situ hybridization histochemistry the distribution of growth hormone (GH) receptor mRNA was examined in the rat brain stem and spinal cord. Dense labeling was seen in the arcuate nucleus of the hypothalamus, as reported previously, but also in several other areas, including the locus coeruleus, the area postrema, and the commissural part of the nucleus of the solitary tract. Other labeled structures included the superior lateral parabrachial nucleus, the facial, hypoglossal and trigeminal motor nuclei, the nucleus incertus, the dorsal tegmental nucleus, the dorsal raphe nucleus, the nucleus of the trapezoid body, and the superficial layers of the dorsal horn of the spinal cord. These findings provide support for a direct action of GH on brain regions involved in various aspects of homeostatic control. Thus, the distribution of GH receptor mRNA to visceral sensory and motor structures is consonant with a role of GH in the regulation of food intake and energy homeostasis. Its presence in the superficial dorsal horn of the spinal cord indicates a role for GH in the initial processing of fine afferent input, and may help explain the beneficial effects of GH replacement in certain unclear pain conditions.
通过原位杂交组织化学方法，研究了生长激素（GH）受体mRNA在大鼠脑干和脊髓中的分布。正如先前报道的那样，在下丘脑弓状核中可见密集标记，但在其他几个区域也有，包括蓝斑、最后区和孤束核的连合部。其他标记结构包括外侧上橄榄核、面神经核、舌下神经核和三叉神经运动核、不确定核、背侧被盖核、中缝背核、斜方体核以及脊髓背角浅层。这些发现支持了生长激素对参与稳态控制各个方面的脑区具有直接作用。因此，生长激素受体mRNA在内脏感觉和运动结构中的分布与生长激素在食物摄入和能量稳态调节中的作用相一致。其在脊髓背角浅层的存在表明生长激素在精细传入输入的初始处理中起作用，这可能有助于解释生长激素替代疗法在某些不明疼痛状况下的有益效果。
