Locke G R, Zinsmeister A R, Fett S L, Melton L J, Talley N J
Division of Gastroenterology and Internal Medicine, and Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Neurogastroenterol Motil. 2005 Feb;17(1):29-34. doi: 10.1111/j.1365-2982.2004.00581.x.
Although the Rome criteria define a number of individual functional gastrointestinal disorders, people may have symptoms of multiple disorders at the same time. In addition, therapies may be effective in subsets of people with specific disorders, yet at the same time help people with multiple disorders.
To estimate the prevalence of combinations of gastrointestional (GI) symptom complexes.
A valid self report questionnaire which records GI symptoms was mailed to an age- and gender-stratified random sample of Olmsted County, MN residents aged 30-64 years. Standard definitions were used to identify people with gastro-oesophageal reflux, dyspepsia, irritable bowel syndrome (IBS), constipation and diarrhoea. The prevalence of people meeting multiple symptom complexes was estimated. Specifically, combinations of dyspepsia, IBS and constipation were compared to dyspepsia, IBS and diarrhoea.
A total of 657 (69%) of 943 eligible subjects responded; 643 provided data for each of the necessary symptom questions. Each two-way combination of symptom group was present in between 4 and 9% of the population; each three-way combination was present in 1-4% of the population. The overlap between dyspepsia, IBS and constipation was similar to dyspepsia, IBS and diarrhoea, except body mass index was higher in the diarrhoea overlap group (P = 0.03).
Symptom complex overlap is common in the community; for each condition, the majority of sufferers reported an additional symptom complex. This overlap of symptoms challenges the current paradigm that functional GI disorders represent multiple discreet entities.
尽管罗马标准定义了多种个体功能性胃肠疾病，但人们可能同时出现多种疾病的症状。此外，治疗方法可能对特定疾病的部分患者有效，但同时也能帮助患有多种疾病的患者。
评估胃肠（GI）症状复合体组合的患病率。
向明尼苏达州奥姆斯特德县30 - 64岁年龄和性别分层的随机样本居民邮寄一份记录GI症状的有效自填问卷。采用标准定义来识别患有胃食管反流、消化不良、肠易激综合征（IBS）、便秘和腹泻的人群。估计符合多种症状复合体的人群患病率。具体而言，比较消化不良、IBS和便秘的组合与消化不良、IBS和腹泻的组合。
943名符合条件的受试者中，共有657名（69%）做出回应；643名提供了每个必要症状问题的数据。症状组的每种双向组合在人群中的占比为4%至9%；每种三向组合在人群中的占比为1%至4%。消化不良、IBS和便秘之间的重叠情况与消化不良、IBS和腹泻相似，但腹泻重叠组的体重指数更高（P = 0.03）。
症状复合体重叠在社区中很常见；对于每种疾病，大多数患者报告还存在另外一种症状复合体。这种症状重叠对功能性胃肠疾病代表多个离散实体的当前范式提出了挑战。
