Gunaruwan Prasad, Schmitt Matthias, Sharman James, Lee Leong, Struthers Alan, Frenneaux Michael
Department of Cardiovascular Medicine, Medical School, University of Birmingham, Edgbaston, Birmingham, United Kingdom.
Am J Cardiol. 2005 Feb 1;95(3):412-4. doi: 10.1016/j.amjcard.2004.09.047.
The nongenomic effects of aldosterone in disease states associated with endothelial dysfunction may differ from those in healthy subjects. The effects of locally infused aldosterone on the forearm blood flow and volume were studied in optimally treated patients with chronic heart failure (CHF). At baseline and after incremental intrabrachial aldosterone, forearm blood flow was assessed using conventional strain gauge plethysmography, and forearm venous volume was assessed by radionuclide plethysmography. Constriction of the resistance vasculature of the forearm without significant effect on forearm venous capacitance was demonstrated in response to aldosterone in patients treated for CHF.
