Serena Carolina, Pastor F Javier, Gilgado Félix, Mayayo Emilio, Guarro Josep
Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili. Carrer Sant Llorenç, 21 43201 Reus, Spain.
Antimicrob Agents Chemother. 2005 Feb;49(2):497-502. doi: 10.1128/AAC.49.2.497-502.2005.
Using a murine model of disseminated infection caused by Trichosporon asahii, we have evaluated the efficacies of amphotericin B (AMB; 1 mg/kg of body weight/day), fluconazole (FLC; 20 mg/kg/twice a day), and micafungin (MFG; 5 mg/kg/twice a day). We tested these drugs alone and in combination (MFG with AMB and MFG with FLC). MFG with AMB showed a synergistic effect and demonstrated a higher degree of efficacy in prolonging survival and reducing the kidney fungal burden than either agent alone. The combination MFG with FLC was able to reduce significantly the kidney fungal burden in comparison to that achieved with either drug administered alone.
利用日本毛孢子菌引起的播散性感染小鼠模型,我们评估了两性霉素B(AMB;1毫克/千克体重/天)、氟康唑(FLC;20毫克/千克/每日两次)和米卡芬净(MFG;5毫克/千克/每日两次)的疗效。我们分别测试了这些药物以及联合用药(MFG与AMB联合、MFG与FLC联合)。MFG与AMB联合显示出协同效应,在延长生存期和降低肾脏真菌负荷方面比单独使用任何一种药物都具有更高的疗效。与单独使用任何一种药物相比,MFG与FLC联合用药能够显著降低肾脏真菌负荷。