低出生体重儿母乳获得性巨细胞病毒感染的发病率及临床表现

Incidence and clinical manifestations of breast milk-acquired Cytomegalovirus infection in low birth weight infants.

作者信息

Miron Dan, Brosilow Sharon, Felszer Klari, Reich Dan, Halle David, Wachtel Daniel, Eidelman Arthur I, Schlesinger Yechiel

机构信息

Pediatric Infectious Disease Consultation Service, Ha'Emek Medical Center, Afula, Rappaport School of Medicine, Haifa, Israel.

出版信息

J Perinatol. 2005 May;25(5):299-303. doi: 10.1038/sj.jp.7211255.

DOI:10.1038/sj.jp.7211255

PMID:15674408

Abstract

OBJECTIVES

To determine the incidence and clinical manifestations of human breast milk (HMB)-associated acquired cytomegalovirus (CMV) infection in small premature infants.

STUDY DESIGN

A prospective study of premature infants born at or prior to 32 weeks gestation, and or infants weighing 1500 g or less at birth. The babies were divided into two groups: Group 1 included babies of CMV seropositive mothers who received HBM throughout the study period. Group 2 included babies of seronegative mothers or babies that did not receive HBM at all. Urine sample were obtained once weekly from birth until the age of 8 weeks or until discharge and were tested for the presence of CMV-DNA by PCR.

RESULTS

Four of 70 infants from group 1 (5.7%, 95% CI, 0 to 11%) acquired CMV infection between the ages of 3 and 7 weeks as compared to none of 26 babies in group 2. Only one infected baby had severe CMV disease with complete recovery.

CONCLUSION

The relative incidence of HBM-associated CMV infection and the severity of HBM-associated CMV disease in premature infants are low.

摘要

目的

确定小早产儿中与人类母乳（HMB）相关的获得性巨细胞病毒（CMV）感染的发生率及临床表现。

研究设计

一项对妊娠32周及以前出生的早产儿或出生体重1500克及以下婴儿的前瞻性研究。婴儿被分为两组：第1组包括在整个研究期间接受母乳的CMV血清学阳性母亲的婴儿。第2组包括血清学阴性母亲的婴儿或完全未接受母乳的婴儿。从出生到8周龄或直至出院，每周采集一次尿液样本，通过聚合酶链反应（PCR）检测CMV-DNA的存在情况。