Mussi-Pinhata Marisa Márcia, Yamamoto Aparecida Yulie, do Carmo Rego Maria Aparecida, Pinto Patrícia Cristina Gomes, da Motta Márcia Soares Freitas, Calixto Cristina
Department of Pediatrics, University of São Paulo School of Medicine, Brazil.
J Pediatr. 2004 Nov;145(5):685-8. doi: 10.1016/j.jpeds.2004.07.025.
In a prospective study, we evaluated the frequency, correlates, and clinical significance of perinatal or early-postnatal cytomegalovirus (CMV) infection in <34-week-gestation infants (n=95) born to CMV-seropositive mothers. None had congenital CMV infection. Overall, 21 (22.1%; 95% CI=14.2-31.8) infants were found to be infected; 10 excreted CMV at <60 days, and 11 had later excretion. Blood transfusion, birth weight, and vaginal delivery were not associated factors. Receiving natural breast milk within the first 30 days (OR=4.5, P=.02) or for >30 days (OR=7.9, P <.01) was associated with infection. Only one (4.8%) of the infected infants was symptomatic. For <34-week-gestation infants, frequency of perinatal and early-postnatal CMV infection is high. Early or prolonged exposure to breast milk is an associated factor. However, most infections are asymptomatic, indicating that CMV infection in preterm infants within such a population is a serious problem infrequently.
在一项前瞻性研究中，我们评估了巨细胞病毒（CMV）血清反应阳性母亲所生的孕周<34周的婴儿（n = 95）围产期或产后早期CMV感染的频率、相关因素及临床意义。无一例有先天性CMV感染。总体而言，发现21例（22.1%；95%CI = 14.2 - 31.8）婴儿感染；10例在60天内排出CMV，11例随后排出。输血、出生体重和阴道分娩均不是相关因素。在出生后30天内接受天然母乳（OR = 4.5，P = 0.02）或超过30天（OR = 7.9，P < 0.01）与感染相关。仅一例（4.8%）感染婴儿有症状。对于孕周<34周的婴儿，围产期和产后早期CMV感染频率很高。早期或长期接触母乳是一个相关因素。然而，大多数感染是无症状的，表明该人群中早产儿的CMV感染很少是一个严重问题。
