Facino R M, Carini M, Traldi P
Istituto Chimico Farmaceutico Tossicologico, Universita di Milano, Italy.
Biol Mass Spectrom. 1992 Apr;21(4):195-201. doi: 10.1002/bms.1200210404.
A collisional spectroscopy procedure for simultaneous detection of five widely employed benzimidazole anthelmintics (laevamisole, thiabendazole, mebendazole, fenbendazole, febantel) in sheep milk was developed. The method which involves injection of crude milk extracts and selection and collision of the most abundant ionic species (M+. or fragments) obtained under electron impact ionization, is highly suitable for multi-residue analysis because of its sensitivity (limits of detection in the range of 0.6-2.8 p.p.b) and its rapidity (more than five samples per hour can be processed). The collisional approach was applied successfully for monitoring of anthelmintic residues in sheep milk.
开发了一种碰撞光谱法，用于同时检测羊奶中五种广泛使用的苯并咪唑驱虫药（左旋咪唑、噻苯达唑、甲苯达唑、芬苯达唑、非班太尔）。该方法包括注入粗制奶提取物，以及对在电子轰击电离下获得的最丰富离子物种（M⁺或碎片）进行选择和碰撞，因其灵敏度（检测限在0.6 - 2.8 ppb范围内）和快速性（每小时可处理超过五个样品）而非常适合多残留分析。碰撞方法已成功应用于监测羊奶中的驱虫药残留。
