Tai S S, Cargile N, Barnes C J
National Institute of Standards and Technology, Organic Analytical Division, Gaithersburg, MD 20899.
J Assoc Off Anal Chem. 1990 May-Jun;73(3):368-73.
The liquid chromatographic determination previously developed for benzimidazoles in cattle liver has been slightly modified and applied to the determination of 4 benzimidazoles in milk. Recoveries of fenbendazole (FBZ), oxfendazole (OFZ), and thiabendazole (TBZ) from milk fortified at the 10 ppb level were 80% or greater with an intralaboratory coefficient of variation of 11% or less. Recovery of 5-hydroxythiabendazole (5-OH-TBZ) at the 30 ppb level averaged 56% with an intralaboratory coefficient of variation of 5%. Limited data on the depletion of FBZ, OFZ, TBZ, and 5-OH-TBZ in milk were also generated.
先前开发的用于测定牛肝中苯并咪唑类药物的液相色谱法略有改进，并应用于牛奶中4种苯并咪唑类药物的测定。在10 ppb水平下加标牛奶中，芬苯达唑（FBZ）、奥芬达唑（OFZ）和噻苯达唑（TBZ）的回收率为80%或更高，实验室内变异系数为11%或更低。在30 ppb水平下，5-羟基噻苯达唑（5-OH-TBZ）的回收率平均为56%，实验室内变异系数为5%。还生成了关于牛奶中FBZ、OFZ、TBZ和5-OH-TBZ消耗的有限数据。
