Maeda Naoki, Hada Takahiko, Murakami-Nakai Chikako, Kuriyama Isoko, Ichikawa Hideki, Fukumori Yoshinobu, Hiratsuka Junichi, Yoshida Hiromi, Sakaguchi Kengo, Mizushina Yoshiyuki
Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University, Nishi-ku, Kobe, Hyogo 651-2180, Japan.
J Nutr Biochem. 2005 Feb;16(2):121-8. doi: 10.1016/j.jnutbio.2004.08.005.
We succeeded in purifying the major glycolipid fraction in the class of sulfoquinovosyl diacylglycerol, monogalactosyl diacylglycerol and digalactosyl diacylglycerol (DGDG) from a green vegetable, spinach (Spinacia oleracea L.). This glycolipid fraction was an inhibitor of DNA polymerases and a growth inhibitor of NUGC-3 human gastric cancer cells, and, interestingly, the activities were much stronger when the fraction was hydrolyzed by lipase. Glycolipids in the hydrolyzed fraction consisted of sulfoquinovosyl monoacylglycerol (SQMG), monogalactosyl monoacylglycerol (MGMG) and DGDG. In the in vivo antitumor assay using Greene's melanoma, the fraction containing SQMG, MGMG and DGDG showed to be a promising suppressor of solid tumors. Spinach glycolipid fraction might be a potent antitumor compound if directly injected into a tumor-carrying body, and this fraction may be a healthy food material that has antitumor activity.
我们成功地从绿色蔬菜菠菜（Spinacia oleracea L.）中纯化出了磺基喹喔啉二酰基甘油、单半乳糖基二酰基甘油和二半乳糖基二酰基甘油（DGDG）类中的主要糖脂部分。该糖脂部分是DNA聚合酶的抑制剂以及NUGC - 3人胃癌细胞的生长抑制剂，有趣的是，当该部分被脂肪酶水解后，其活性更强。水解部分中的糖脂由磺基喹喔啉单酰基甘油（SQMG）、单半乳糖基单酰基甘油（MGMG）和DGDG组成。在使用格林氏黑色素瘤的体内抗肿瘤试验中，含有SQMG、MGMG和DGDG的部分显示出是实体瘤的一种有前景的抑制剂。如果直接注射到荷瘤体内，菠菜糖脂部分可能是一种有效的抗肿瘤化合物，并且该部分可能是一种具有抗肿瘤活性的健康食品原料。
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