Matsubara Kiminori, Matsumoto Hiroaki, Mizushina Yoshiyuki, Mori Masaharu, Nakajima Nobuyoshi, Fuchigami Michiko, Yoshida Hiromi, Hada Takahiko
Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan.
Oncol Rep. 2005 Jul;14(1):157-60.
Anti-cancer activity of some glycolipids from animals and plants has been demonstrated, although it was unknown whether the glycolipids had anti-angiogenic activity. The effects of the purified three glycolipids, monogalactosyl diacylglycerol (MGDG), digalactosyl diacylglycerol (DGDG), and sulfoquinovosyl diacylglycerol (SQDG) from the green vegetable spinach (Spinacia oleracea L.) were examined on in vitro and ex vivo angiogenesis models. MGDG and SQDG suppressed microvessel growth in an ex vivo angiogenesis model using a rat aortic ring. The glycolipids inhibited human umbilical vein endothelial cell (HVUEC) tube formation on a reconstituted basement membrane and HUVEC proliferation. These results demonstrate that glycolipids from spinach would suppress tumor growth by suppressing angiogenesis and might be candidates for anti-cancer or anti-angiogenic materials.
一些动植物糖脂的抗癌活性已得到证实，尽管尚不清楚这些糖脂是否具有抗血管生成活性。研究了从绿色蔬菜菠菜（Spinacia oleracea L.）中纯化得到的三种糖脂，即单半乳糖基二酰基甘油（MGDG）、二半乳糖基二酰基甘油（DGDG）和磺基喹喔啉基二酰基甘油（SQDG）对体外和体内血管生成模型的影响。MGDG和SQDG在使用大鼠主动脉环的体内血管生成模型中抑制了微血管生长。这些糖脂抑制了重组基底膜上的人脐静脉内皮细胞（HVUEC）管形成以及HUVEC增殖。这些结果表明，菠菜中的糖脂可能通过抑制血管生成来抑制肿瘤生长，并且可能是抗癌或抗血管生成材料的候选物。
