Heijkants Ralf G J C, van Calck Ralph V, van Tienen Tony G, de Groot Jacqueline H, Buma Pieter, Pennings Albert J, Veth Reen P H, Schouten Arend Jan
Department of Polymer Chemistry, Faculty of Mathematics & Natural Sciences, University Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.
Biomaterials. 2005 Jul;26(20):4219-28. doi: 10.1016/j.biomaterials.2004.11.005.
Polyurethanes based on poly(epsilon-caprolactone) (PCL) (750-2800 g/mol) and 1,4-butane diisocyanate (BDI) with different soft segment lengths and constant uniform hard segment length were synthesized in absence of catalysts for the production of a degradable meniscus scaffold. First the polyesterdiols were endcapped with BDI yielding a macrodiisocyanate with a minimal amount of side reactions and a functionality of 2.0. Subsequently, the macrodiisocyanates were extended with 1,4-butanediol in order to obtain the corresponding polyurethane. The polyurethanes had molecular weights between 78 and 160 kg/mol. Above molar masses of 1900 g/mol of the polyesterdiol crystalline PCL was found while the hard segment showed an increase in melting point from 78 to 122 degrees C with increasing hard segment content. It was estimated that the percentage crystallinity of the hard segment varied between 92 and 26%. The Young's modulus varied between 30 and 264 MPa, the strain at break varied between 870 and 1200% and tear strengths varied between 97 and 237 kJ/m2.
以聚(ε-己内酯)(PCL)(750 - 2800 g/mol)和1,4 - 丁二异氰酸酯(BDI)为基础,在无催化剂条件下合成了具有不同软段长度和恒定均匀硬段长度的聚氨酯,用于制备可降解半月板支架。首先,用BDI对聚酯二醇进行封端,得到副反应最少且官能度为2.0的大分子二异氰酸酯。随后,用1,4 - 丁二醇对大分子二异氰酸酯进行扩链,以得到相应的聚氨酯。这些聚氨酯的分子量在78至160 kg/mol之间。当聚酯二醇的摩尔质量高于1900 g/mol时,发现有结晶性的PCL,而硬段的熔点随着硬段含量的增加从78℃升高到122℃。据估计,硬段的结晶度百分比在92%至26%之间变化。杨氏模量在30至264 MPa之间变化,断裂应变在870%至1200%之间变化,撕裂强度在97至237 kJ/m²之间变化。