Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry RAS, 142432 Chernogolovka, Russia.
Scientific Center in Chernogolovka RAS, 142432 Chernogolovka, Russia.
Int J Mol Sci. 2022 Nov 1;23(21):13344. doi: 10.3390/ijms232113344.
Fullerene derivatives are of great interest in various fields of science and technology. Fullerene derivatives are known to have pronounced anticancer and antiviral activity. They have antibacterial properties. Their properties are largely determined by association processes. Understanding the nature and properties of associates in solvents of various types will make it possible to make significant progress in understanding the mechanisms of aggregation of molecules of fullerene derivatives in solutions. Thus, this work, aimed at studying the size and stability of associates, is relevant and promising for further research. The NMR method in a pulsed field gradient was used, which makes it possible to directly study the translational mobility of molecules. The sizes of individual molecules and associates were calculated based on the Stokes-Einstein model. The lifetime of associates was also estimated. The interaction of water-soluble C fullerene derivatives with erythrocytes was also evaluated. The values of self-diffusion coefficients and the lifetime of molecules of their compounds in cell membranes are obtained. It is concluded that the molecules of fullerene derivatives are fixed on the cell surface, and their forward movement is controlled by lateral diffusion.
富勒烯衍生物在科学技术的各个领域都具有重要的应用价值。已知富勒烯衍生物具有显著的抗癌和抗病毒活性。它们具有抗菌特性。它们的性质在很大程度上取决于缔合过程。了解各种类型溶剂中缔合物的性质和结构，将有助于在理解富勒烯衍生物分子在溶液中聚集的机制方面取得重大进展。因此，这项旨在研究缔合物大小和稳定性的工作，对于进一步的研究具有相关性和前景。该研究采用了脉冲梯度磁场中的 NMR 方法，该方法可直接研究分子的平移流动性。基于斯托克斯-爱因斯坦模型计算了各个分子和缔合物的大小，并估算了缔合物的寿命。还评估了水溶性 C 富勒烯衍生物与红细胞的相互作用，得到了它们化合物在细胞膜中的自扩散系数和分子寿命值。研究结论认为，富勒烯衍生物的分子固定在细胞表面，它们的前进运动受到侧向扩散的控制。
