RNA聚合酶I和III、生长控制与癌症。

RNA polymerases I and III, growth control and cancer.

作者信息

White Robert J

机构信息

Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, G12 8QQ, UK.

出版信息

Nat Rev Mol Cell Biol. 2005 Jan;6(1):69-78. doi: 10.1038/nrm1551.

DOI:10.1038/nrm1551

PMID:15688068

Abstract

Transcription of rRNA and tRNA genes by RNA polymerases I and III is essential for sustained protein synthesis and is therefore a fundamental determinant of the capacity of a cell to grow. When cell growth is not required, this transcription is repressed by retinoblastoma protein, p53 and ARF. However, inactivation of these tumour suppressors in cancers deregulates RNA polymerases I and III, and oncoproteins such as Myc can stimulate these systems further. Such events might have a significant impact on the growth potential of tumours.

摘要

RNA聚合酶I和III对rRNA和tRNA基因的转录对于持续的蛋白质合成至关重要，因此是细胞生长能力的一个基本决定因素。当不需要细胞生长时，这种转录会受到视网膜母细胞瘤蛋白、p53和ARF的抑制。然而，癌症中这些肿瘤抑制因子的失活会使RNA聚合酶I和III失调，而Myc等癌蛋白可以进一步刺激这些系统。此类事件可能对肿瘤的生长潜力产生重大影响。