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[妊娠与炎症性肠病]

[Pregnancy and inflammatory bowel disease].

作者信息

Asimakopoulos G

机构信息

Ammerland Klinik Westerstede, Departamentul de Obstetrică şi Ginecologie.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2004 Jan-Mar;108(1):46-50.

Abstract

Inflammatory bowel disease (IBD)--Crohn's disease, ulcerative colitis--affects frequently the women in their childbearing years with concerns about both on pregnancy and evolution of the IBD. Important issues concerning a pregnant woman with IBD include the effect of pregnancy on the disease, and, conversely, the effect of IBD on pregnancy and inheritance of IBD in the offspring. Adverse fetal outcomes are not increased when IBD is inactive; however, women with active disease incur a greater risk of premature birth. Most of women with active IBD at the time of contraception have continued or worsening disease activity during pregnancy. Most medications for IBD are safe during pregnancy, with notable exceptions. A key principle of management is that active disease, not therapy, poses the greatest risk to pregnancy.

摘要

炎症性肠病(IBD)——克罗恩病、溃疡性结肠炎——在育龄期女性中较为常见,她们对怀孕以及IBD的病情发展都很担忧。患有IBD的孕妇的重要问题包括怀孕对疾病的影响,反之,IBD对怀孕的影响以及IBD在后代中的遗传情况。当IBD处于非活动期时,不良胎儿结局不会增加;然而,患有活动期疾病的女性早产风险更高。大多数在避孕时患有活动期IBD的女性在怀孕期间病情持续或恶化。大多数用于治疗IBD的药物在孕期是安全的,但有明显例外。治疗的一个关键原则是,活动期疾病而非治疗对怀孕构成最大风险。

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