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[炎症性肠病与妊娠]

[Inflammatory bowel disease and pregnancy].

作者信息

Duvnjak Marko, Lerotić Ivan, Tomasić Vedran, Pavić Tajana, Virović Lucija

机构信息

Zavod za gastroenterologiju i hepatologiju, Klinika za unutarnje bolesti, Klinicka bolnica Sestre milosrdnice, Zagreb.

出版信息

Lijec Vjesn. 2006 Jan-Feb;128(1-2):48-55.

Abstract

Inflammatory bowel diseases (IBD) can affect women of childbearing potential. There are many issues to consider in female patients with IBD who are contemplating pregnancy, such as influence of the disease on fertility or pregnancy outcome, effect of the gestation on the course of the disease, safety of the drugs and inheritance of the disease in the offspring. It is important to remember that the outcome of the pregnancy is dependent mostly on the activity of the disease at the time of conception and there is no increase of the adverse events in patients with quiescent bowel disease. With few exceptions, majority of medications used in the treatment of IBD are safely used during pregnancy and breastfeeding. This article reviews the most recent knowledge regarding the effects of IBD and their treatment on fertility and pregnancy, therapeutic options and outcomes in patients who are planning pregnancy or who are pregnant or lactating.

摘要

炎症性肠病(IBD)会影响有生育潜力的女性。对于正在考虑怀孕的IBD女性患者,有许多问题需要考虑,例如疾病对生育能力或妊娠结局的影响、妊娠对疾病进程的作用、药物安全性以及疾病在后代中的遗传情况。重要的是要记住,妊娠结局主要取决于受孕时疾病的活动情况,静止期肠道疾病患者的不良事件不会增加。除少数例外情况外,治疗IBD所用的大多数药物在妊娠和哺乳期均可安全使用。本文综述了关于IBD及其治疗对生育能力和妊娠的影响、治疗选择以及计划怀孕、已怀孕或正在哺乳的患者的治疗结局的最新知识。

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