Pillai Shiv
Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA.
J Clin Invest. 2005 Feb;115(2):224-7. doi: 10.1172/JCI24238.
Inositol-requiring enzyme 1 (IRE1) is a transmembrane protein that signals from the ER and contributes to the generation of an active spliced form of the transcriptional regulator X-box-binding protein 1 (XBP1). XBP1 is required for the terminal differentiation of B lymphocytes into plasma cells, and IRE1 also participates in this differentiation event. A study in this issue of the JCI reveals, quite unexpectedly, that IRE1 is also required early in B lymphocyte development for the induction of the machinery that mediates Ig gene rearrangement.
肌醇需求酶1(IRE1)是一种跨膜蛋白,它从内质网发出信号,并有助于生成转录调节因子X盒结合蛋白1(XBP1)的活性剪接形式。B淋巴细胞向浆细胞的终末分化需要XBP1,IRE1也参与了这一分化过程。本期《临床研究杂志》上的一项研究出人意料地发现,在B淋巴细胞发育早期,诱导介导Ig基因重排的机制也需要IRE1。